Cytovance has 10+ years of experience developing processes for scale-up into our manufacturing suites. Our dedicated cell culture process development team of experts works closely with Manufacturing Sciences & Technology (MS&T) and Manufacturing to develop scaleable manufacturing processes. Cytovance has developed platform bioreactor processes for CHO-S, CHO-K1, and DG44 cell lines.
Cytovance® Biologics develops and executes batch, fed-batch, and perfusion bioreactor processes. These cell culture processes are developed and optimized to meet future commercial requirements through a combination of screening, media analyses and supplementation, productivity analysis, and systematic optimization of parameters.
Our Services include:
Cell propagation in stirred-tanked bioreactors, flasks, Wave® Bioreactor, HYPERStack® Cell Culture Vessel, roller bottles, and spinner flasks
Feed media screening and feed strategies development
Adaptation of cell lines to chemically defined, protein free and animal component free cGMP compliant media
Experience with a variety of systems, including CHO DG44/DHFR-, and proprietary expression technologies from Lonza, Selexis, Catalent, and others.
Bioreactor parameter optimization
Scaled-down production batches